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Endometriotic cells resist programmed cell death in women with endometriosis

Endometriotic cells resist programmed cell death in women with endometriosis

According to a study from the United States, "apoptosis is a physiologic process that deletes unwanted cells without inducing an inflammatory reaction. Survival of endometriotic implants is associated with decreased apoptosis and an inflammatory environment. The most widely accepted theory - transplantation theory related to the pathogenesis of endometriosis is supported by the description of abnormal survival of regurgitated endometrial cells." 

"Eutopic endometrial cells from women with endometriosis also seem to resist apoptosis further when compared with cells from disease-free women. Several apoptotic pathways have been studied," J.A. Garcia-Velasco and colleagues, Yale University, School of Medicine pointed out. 

"Recent literature concerning apoptosis-related genes such as bcl-2/bax and fas/fas ligand is summarized in this article. Special emphasis is placed on sex steroid modulation and cell adhesion regulation, both relevant in early events of endometriosis." 

Garciavelasco and colleagues published the results of their research in Seminars in Reproductive Medicine (Apoptosis and the pathogenesis of endometriosis. Semin Reprod Med, 2003;21(2):165-172). 

For additional information, contact A. Arici, Yale University, School of Medicine, Reproductive Endocrinology & Infertility Section, Department of Obstetrics & Gynecology, 333 Cedar St., New Haven, CT 06520, USA.