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Endometriosis Zone editorial advisor
Bruno Lunenfeld, MDProfessor Emeritus, Reproductive Endocrinology, Bar-Ilan University, Ramat Gan, Israel Research Interests and Goals: Physiology and pathology of male and female reproduction. Stimulators, modulators and regulators of spermatogenesis and spermiogenesis. Stimulators, modulators, and regulators of folliculogenesis and ovulation. Mechanism of action of gonadotropins and growth factors on gene expression and steroidogenesis. Molecular mechanism of cell proliferation and cell death in hormone dependent tumors. Previous and Current Research: Characterized the chemical and biological nature of human menopausal gonadotropins and discovered their use in male and female infertility. With his collaborators he established a diagnostic, therapeutic oriented, classification system for male and female infertility. Proposed guidelines for the management of infertility and designed effective treatment protocols. Research focused on the understanding of mechanisms controlling the hypothalamic-pituitary gonadal and adrenal axis and in the understanding of the nature, development and pathogenesis of diseases leading to functional abnormalities in this axis. Current research involves: 1) subcellular and molecular nature of granulosa cell response to gonadotropins, growth factors and binding globulins. 2) Effects of gonadotropins on spermatogenesis and spermiogenesis. Interests and Future projects: The mode of action of gonadotropins, growth factors and their binding globulins in ovarian and testicular regulation and function. The application of results of such basic research to clinical diagnostic preventive and therapeutic strategies. Development of strategies in teaching and transfer of technology related to endocrinology and reproduction.
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