Endometriosis Zone editorial advisor

Serdar E. Bulun, MD

Professor and Friends of Prentice Distinguished Physician 
Chief, Division of Reproductive Biology Research 
Dept of Obstetrics and Gynecology 
Northwestern University Feinberg School of Medicine

EDUCATION:

• 1973 - 1977 American Robert College, Istanbul, Turkey
• 1977 - 1983 Doctor of Medicine, Istanbul University School of Medicine, Istanbul, Turkey 
• 1983 - 1986 Family Practice, Gazipasa Hospital, Antalya, Turkey
• 1986 - 1987 Residency: Pathology, University of Arizona College of Medicine, Tucson, AZ
• 1987 - 1988 Internship: Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York
• 1988 - 1991 Residency: Obstetrics and Gynecology, State University of New York at Buffalo
• 1991 - 1993 Subspecialty Fellowship (Reproductive Endocrinology and Infertility), University of Texas Southwestern Medical Center at Dallas

PAST ACADEMIC APPOINTMENTS:

• 1993 - 1999 Assistant Professor of Obstetrics and Gynecology
  Green Center for Reproductive Biology Sciences
  University of Texas Southwestern Medical Center at Dallas
• 1997 - 1999 Associate Director of Reproductive Endocrinology Fellowship Program
  University of Texas Southwestern Medical Center at Dallas

CURRENT POSITION:
Feb 1999 - present Associate Professor of Obstetrics and Gynecology and Molecular Genetics
Director, Division of Reproductive Endocrinology
University of Illinois at Chicago

CERTIFICATIONS:

• Board certified in Obstetrics and Gynecology, 1994
• Board certified in Reproductive Endocrinology and Infertility, 1996

HONORS

Editorial Board: Journal of Clinical Endocrinology and Metabolism, 1998-2002

Scientific Review Panels: Specialized Centers Of Research (SCOR) on Sex and Gender Factors Affecting Women’s Health, NIH, 2002
Reproductive Endocrinology (REN) Study Section Member, NIH, 2001-2005
Reproductive Endocrinology (REN) Study Section, NIH (ad hoc reviewer), 2000
Biochemical Endocrinology (BCE) Study Section , NIH (ad hoc reviewer), 2000
Endocrinology Review Panel, Department of Defense Breast Cancer Research Program, 1996-1999

Chair: Society for Gynecologic Investigation Meeting, Los Angeles, CA, 2002

Board Examiner: Subspecialty Board in Reproductive Endocrinology and Infertility, 2002

Invited expert to:

• National Clinical Research Panel sponsored by AMA and AAMC, Chicago, IL, 1998
• In Vitro Fertilization Program, King Faisal Specialist Hospital, Riyadh, Saudi Arabia; summer, 1995

Invited speaker to (selected meetings):

• Gordon Research Conference on Hormonal Carcinogenesis, NH, 2003
• 19th European Society of Human Reproduction and Embryology (ESHRE) Meeting, Madrid, Spain, 2003
• Serono International Symposium on Embryo Implantation, Madrid, Spain, 2003
• Society for Gynecologic Investigation Meeting, Chicago, IL, 2003
• 18th European Society of Human Reproduction and Embryology (ESHRE) Meeting, Vienna, Austria 2002
• 2nd International Congress on Menopause and Osteoporosis, Istanbul, Turkey, 2002
• Serono International Symposium on Embryo Implantation, Uncasville, CT, 2002
• Gordon Research Conference on Reproductive Tract Biology, Hartford, CT, 2002
• 1st World Cong on Horm and Gen Basis for Sexual Differentiation, Tempe, AZ, 2002
• 7th International Aromatase Conference, Kyoto, Japan, 2002
• NIH-NCI Workshop on Endometrial Cancer, San Francisco, CA, 2002
• Society for Gynecologic Investigation Meeting, Chicago, IL, 2002
• 3rd World Congress on Endometriosis, San Diego, 2002
• French Endocrine Society Meeting, Lyon, France, 2001
• Serono International Symposium on Embryo Implantation, Madrid, Spain, 2001
• NIH-NICHD Workshop on Endometriosis, Bethesda, MD, 2001
• 6th International Aromatase Conference, Port Douglas, Australia, 2000
• Society for Gynecologic Investigation Meeting, Chicago, IL, 2000 
• Endocrine Society, San Diego, CA, 1999
• 7th Ann Sci Symp, Prince Henry’s Inst of Med Research, Monash Univ, Australia, 1999
• 5th International Congress on Aromatase and its Inhibitors, Prague, Czech Republic, 1998
• 16th World Congress on Fertility and Sterility, San Francisco, CA, 1998
• 1st World Congress on Endometriosis, Quebec City, Canada, 1998
• American Society for Reproductive Medicine Meeting, Cincinnati, OH, 1997
• 9th Reinier de Graaf Symposium, Noordwijk, The Netherlands, 1996
• 4th International Aromatase Conference, Lake Tahoe, CA, 1996
• Society for Gynecologic Investigation Meeting, Philadelphia, PA, 1996
• Society for Gynecologic Investigation Meeting, Chicago, IL, 1995
• 9th International Congress on Hormonal Steroids, Dallas, TX, 1994

Awards:

• Society for Gynecologic Investigation President’s Achievement Award, 2002
• Charles E. Hunter, Jr. Prize Thesis Award, AAOGF, 1999
• Society for Gynecologic Investigation Meeting, President’s Poster Award, 1999
• American Society for Reproductive Medicine Meeting, SRE Prize Paper Award, 1998
• American Society for Reproductive Medicine Meeting, SRE Prize Paper Award, 1996
• AAOGF – Walter Dannreuther Fellow, 1994-96
• Society for Gynecologic Investigation Meeting, President’s Poster Award, 1995
• American Fertility Society Meeting, SRE Prize Paper Award, 1992
• Marcos Gallego Award by S.U.N.Y. at Buffalo Dept. of Ob/Gyn, 1991
• Buffalo Gynecologic and Obstetric Society Award for Clinical Excellence, 1990

Committees:

• Dean’s Committee for the “Merger of Department of Molecular Genetics and Department of Biochemistry and Molecular Biology”, UIC Col of Med (1999-2000)
• Dean’s Search Committee for the Chair of Department of Molecular Genetics and Biochemistry, UIC Col of Med (2001-present)

SCIENTIFIC AND PROFESSIONAL SOCIETY MEMBERSHIPS:

Society for Gynecologic Investigation, Endocrine Society, American Society for Reproductive Medicine, Fellow-American College of Obstetricians and Gynecologists, Society of Reproductive Endocrinologists, American Medical Association

HOSPITAL STAFF APPOINTMENTS:

• University of Illinois at Chicago Medical Center (current)
• Parkland Memorial Hospital, Dallas, TX
• St. Paul Hospital, Dallas, TX
• Zale-Lipshy University Hospital, Dallas, TX

TEACHING:

• 1999-present Didactic Teaching, Molecular Genetics (University of Illinois at Chicago); Molecular Genetics of Hormone Production; first year medical students; lecturer.
• 1999-present Didactic Teaching, Obstetrics-Gynecology (University of Illinois at Chicago); Reproductive Endocrinology and Infertility; third year medical students; lecturer.
• 1997-1999: Associate Fellowship Director of Reproductive Endocrinology Program, Dept. of Obstetrics-Gynecology
• 1996-1999: Didactic Teaching, Obstetrics-Gynecology (UT Southwestern Med School in Dallas); Reproductive Endocrinology and Infertility; third and fourth year medical students; lecturer.
• 1994-1999: In charge of weekly Green Center Clinical Conferences for Reproductive Endocrinology Fellows

Graduate Ph.D. Students

• Sanober Amin, MS; Molecular Genetics, UIC (2000-present)
• Bertan Yilmaz, MS; Molecular Genetics, UIC (2001-present)

M.D. Students (Research Fellowship)

• Joanne Rink, MS II (see scientific papers #18 and 20)
  1994 Medical Student Summer Research Fellowship Program 
  33rd Southwestern Medical School Research Forum (awarded an oral presentation)
  “Distribution of Fibroblasts and Aromatase P450 Transcripts in Breast Adipose Tissue” 
  (Also presented during the 1995 National Student Research Forum, Galveston, TX)
• Jeff Smok, MS III (July-August 1995) (Medical Student from Poland rotating at UTSWMC)
  “Regulation of Aromatase P450 in Hepatocellular Cancer Cells”

Postdoctoral Fellows

• John Nichols, M.D. (1993-1995)
  Current position: Assistant Professor, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, East Carolina University School of Medicine, Greenville, NC
• Luis Noble, M.D. (1994-1996) 
  Current position: Reproductive Endocrinology, Columbia West-HCA Hospital, El Paso, Texas.
• Kazuto Takayama, M.D. (1995-1997)
  Current position: Assistant Professor, Department of Obstetrics and Gynecology
  Tohoku University School of Medicine
  Sendai, Japan
• Makio Shozu, M.D. (1997-1998)
  Current position: Associate Professor, Department of Obstetrics and Gynecology
  Kanazawa University School of Medicine
  Kanazawa, Japan
• Khaled Zeitoun, M.D. (1996-2000) 
  Fellow in Reproductive Endocrinology and Infertility Program of Dept. of Obstetrics-Gynecology, UT Southwestern Medical Center at Dallas (1996-1999) 
  Dr. Zeitoun was awarded an American Association of Obstetricians and Gynecologists Fellowship grant ($144,000 award, 1998-2001) under the mentorship of Serdar E. Bulun.
  Current position: Assistant Professor, Department of Obstetrics and Gynecology
  Columbia University College of Physicians and Surgeons, New York
• Hiroshi Murakami, M.D. (1998-1999)
  Current position: Assistant Professor, Department of Surgery
  Tohoku University School of Medicine
  Sendai, Japan
• George Attia, MD (1998-1999)
  Fellow in Reproductive Endocrinology and Infertility Program of Dept. of Obstetrics-Gynecology, UT Southwestern Medical Center at Dallas (1998-1999)
  Current position: Assistant Professor, Department of Obstetrics and Gynecology
  UT Southwestern Medical Center at Dallas
• Oyekunle Akinola, M.D. (1999-2000)
  Current position: Resident in Obstetrics and Gynecology
  Yale Medical School, New Haven, CT
• Jianfeng Zhou, M.D., Ph.D. (1998-2001)
  Current Position: Chairman, Department of Internal Medicine
  Tongji Medical School, University of Wuhan, China 
• Siby Sebastian, Ph.D. (1999-2002)
  Current position: Assistant Professor, Departments of Genetics and Pathology
  Duke University Medical Center, Durham, NC
• Zong juan Fang, M.D. (1998-present)
• Si jun Yang, M.D. (1999-present)
• Bilgin Gurates, M.D. (1999-present)
• Mitsutoshi Tamura, M.D. (1999-present)
• Santanu Deb, Ph.D. (2002-present)

GRANTS:

Active: 

1. NIH U54 Award HD40093; Center for Women’s Health and Reproduction. Co-Director: Serdar E. Bulun, (Director: Asgi Fazleabas), $6,212,984 total award, 2002-2007. Hormone Action in Endometriosis. Project (2) Leader: Serdar E. Bulun, $1,305,626 award, 2002-2007.
2. NIH R01 Award CA67167; Breast Cancer-Proximal Stroma Interactions and Aromatase; Principal Investigator: Serdar E. Bulun, $1,753,540 award, 2002-2007.
3. NIH R01 Award HD38691; Mechanisms of Estrogen Biosynthesis in Endometriosis; Principal Investigator: Serdar E. Bulun, $1,071,062 award, 1999-2003.
4. NIH R03 Award TW01339; Mechanisms of Infertility in Endometriosis; Principal Investigator: Serdar E. Bulun, $122,970 award, 2000-2003.
5. Novartis, Pharma; Treatment of Endometriosis with an Aromatase Inhibitor Principal Investigator: Serdar E. Bulun, $130,000 award, 2001-2003.
6. Astra-Zeneca; Treatment of Endometriosis with an Aromatase Inhibitor; Principal Investigator: Serdar E. Bulun, $100,000 award, 2001-2003.
7. Intercampus Research Initiative in Biotechnology; University of Illinois, Affymetrix Technology Platform for the Genomic Analysis of Women’s Neoplasms; Co-Investigator (Principal Investigator: Carol Westbrook), $450,000 award, 2001-2004.

Previous:

1. Society for Gynecologic Investigation-Mead Johnson Unrestricted Research Grant; Aromatase Expression in Endocrine-Responsive Tumors; Principal Investigator: Serdar E. Bulun, $15,000 award, 1993.
2. American Association of Obstetricians and Gynecologists Foundation (AAOGF) Fellowship Award; Aromatase Enzyme and Breast Cancer; Principal Investigator: Serdar E. Bulun, $96,000 award, 1994-1996
3. Zonagen, Inc., (Houston, Texas) Research Grant; Aromatase Expression in Human Endometrium; Principal Investigator: Serdar E. Bulun, $65,503 award, 1996-1997.
4. American Society for Reproductive Medicine and Organon Unrestricted Research Grant; Development of Molecular Markers for Endometriosis; Principal Investigator: Serdar E. Bulun, $20,000 award, 1997-1998
5. US Army Career Development Award DAMD17-94-J-4188; Breast Cancer and Estrogen Biosynthesis in Adipose Tissue; Principal Investigator: Serdar E. Bulun, $200,000 award, 1994-1998.
6. University of Illinois Center Seed Grant Initiative; Endometriosis: Basic and Clinical Aspects; Co-Director: Serdar E. Bulun, $100,000 award, 1999-2000.
7. National Institutes of Health R29 Award CA67167; Breast Cancer-Proximal Stroma Interactions and Aromatase; Principal Investigator: Serdar E. Bulun, $543,550 award, 1996-2001.
8. American Association of Obstetricians and Gynecologists Foundation (AAOGF) Fellowship Award; Molecular Basis for Estrogen Biosynthesis in Endometriosis: A Target for Novel Treatment Strategies; Principal Investigator: Khaled Zeitoun; Sponsor: Serdar E. Bulun, $144,000 award, 1998-2001.
9. US Army Breast Cancer Research Award DAMD17-97-1-7025; Adipocyte Differentiation: Relationship to Breast Cancer; Principal Investigator: Serdar E. Bulun, $300,000 award, 1997-2002.

PEER-REVIEWED PAPERS:

1. Bulun SE, MS Mahendroo and ER Simpson: PCR amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua. J Clin Endocrinol Metab. 76:1458-63 (1993).

2. Bulun SE, TM Price, J Aitken, MS Mahendroo and ER Simpson: A link between local estrogen biosynthesis and breast cancer suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts by competitive PCR. J Clin Endocrinol Metab. 77:1622-28 (1993). 

3. Bulun SE, IM Rosenthal, A Brodie, AM DiGeorge, S Inkster, WP Zeller, MW Kilgore and ER Simpson: Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads. J Clin Endocrinol Metab. 77:1616-21 (1993).

4. Bulun SE and ER Simpson: Competitive RT-PCR analysis indicates levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with age. J Clin Endocrinol Metab. 78:428-32 (1994).
5. Bulun SE, K Economos, D Miller and ER Simpson: CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors. J Clin Endocrinol Metab. 79:1831-34 (1994).
6. Bulun SE, ER Simpson and RA Word: Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture. J Clin Endocrinol Metab. 78:736-43 (1994).
7. Bulun SE and ER Simpson: Breast cancer and expression of aromatase in breast adipose tissue. Trends in Endocrinol Metab. 5:113-20 (1994).
8. Simpson ER, MS Mahendroo, GD Means, MW Kilgore, MM Hinshelwood, S Graham-Lorence, B Amarneh, Y Ito, CR Fisher, MD Michael, CR Mendelson and SE Bulun: Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev. 15:342-55 (1994).
9. Bulun SE, MS Mahendroo and ER Simpson: Aromatase gene expression in adipose tissue: Relationship to breast cancer. J Steroid Biochem Mol Biol. 49:319-26 (1994).
10. Bulun SE and ER Simpson: Regulation of aromatase expression in human tissues. Breast Cancer Res Treat. 30:19-29 (1994).
11. Nichols JE, SE Bulun and ER Simpson: Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells. J Soc for Gynecol Inves. 2:45-50 (1995).
12. Young S, S Gooneratne, FH Straus, WP Zeller, SE Bulun and IM Rosenthal: Feminizing Sertoli cell tumors in boys with Peutz-Jeghers syndrome. Am J Surgic Pathol. 19:50-58 (1995).
13. Zhao Y, JE Nichols, SE Bulun, CR Mendelson and ER Simpson: Aromatase P450 gene expression in human adipose tissue: Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J Biol Chem. 270:16449-57 (1995).
14. Agarwal V, SE Bulun and ER Simpson: Quantitative detection of alternatively spliced transcripts of the aromatase P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR. Molecular and Cellular Probes. 9:453-64 (1995).
15. Noble LS, ER Simpson, A Johns and SE Bulun: Aromatase expression in endometriosis. J Clin Endocrinol Metab. 81:174-79 (1996).
16. Bulun SE: Clinical Review 78: Aromatase deficiency in women and men: Would you have predicted the phenotypes? J Clin Endocrinol Metab. 81:867-71 (1996).
17. Bulun SE, G Sharda, J Rink, S Sharma and ER Simpson: Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast. J Clin Endocrinol Metab. 81:1273-77 (1996).
18. Crichton MB, JE Nichols, Y Zhao, SE Bulun and ER Simpson: Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells. Mol Cell Endocrinol. 118:215-220 (1996).
19. Rink J, ER Simpson, JJ Barnard and SE Bulun: Cellular characterization of adipose tissue from various body sites of women. J Clin Endocrinol Metab. 81:2443-2447 (1996).
20. Agarwal VR, SE Bulun M Leitch, R Rohrich and ER Simpson: Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. J Clin Endocrinol Metab. 81:3843-3849 (1996).
21. Young J, SE Bulun, V Agarwal, B Couzinet, CR Mendelson, ER Simpson, and G Schaison: Steroid measurements from adrenal veins, aromatase activity and aromatase P450 gene expression in a feminizing adrenal tumor. J Clin Endocrinol Metab. 81:3173-3176 (1996).
22. Sasano H, AR Frost, R Saitoh, N Harada, M Poutanen, R Vihko, SE Bulun, SG Silverberg, H Nagura. Aromatase and 17b-Hydroxysteroid Dehydrogenase Type 1 in Human Breast Carcinoma. J Clin Endocrinol Metab. 81:4042-4046 (1996).
23. Simpson ER, SE Bulun, JE Nichols, and Y Zhao: Estrogen biosynthesis in adipose tissue: regulation by paracrine and autocrine mechanisms. J Endocrinol. 150:S51-S57 (1996).
24. Noble, LS, K Takayama, KM Zeitoun, JM Putman, DA Johns, MM Hinshelwood, VR Agarwal, Y Zhao, BR Carr and SE Bulun: Prostaglandin E2 stimulate aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab. 82:600-606 (1997).
25. Agarwal VR, C Ahsanullah, ER Simpson, and SE Bulun: Alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in adipose tissue of women. J Clin Endocrinol Metab. 82:70-74 (1997).
26. Bulun SE, LS Noble, K Takayama, MD Michael, VR Agarwal, C Fisher, Y Zhao, MM Hinshelwood, Y Ito and ER Simpson: Endocrine disorders associated with inappropriately high aromatase expression. J Steroid Biochem & Mol Biol. 61:133-139 (1997).
27. Takayama K, K Zeitoun, RT Gunby, H Sasano, and SE Bulun: Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertil Steril. 69:709-713 (1998).
28. Agarwal VR, K Takayama, JJ Van Wyk, H Sasano, ER Simpson, and SE Bulun: Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma. J Clin Endocrinol Metab. 83:1797-1800 (1998).
29. Shozu M, Y Zhao, SE Bulun, and ER Simpson: Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6. Endocrinology. 139:1610-117 (1998). 
30. Zeitoun K, K Takayama, H Sasano, T Suzuki, N Moghrabi, S Andersson, A Johns, L Meng, M Putman, B Carr, and SE Bulun: Deficient 17b-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize estradiol-17b. J.Clin Endocrinol Metab. 83:4474-4480 (1998).
31. Zeitoun K, K Takayama, MD Michael, and SE Bulun: Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of SF-1 and COUP-TF to the same cis-acting element. Mol. Endocrinol. 13:239-253 (1999).
32. Zeitoun K and SE Bulun: Aromatase: a key molecule in pathophysiology of endometriosis and a therapeutic target. Fertility and Sterility. 72:961-969 (1999).
33. Bulun SE, K Zeitoun, K Takayama, L Noble, D Michael, E Simpson, A Johns, M Putman, and H Sasano: Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. Endocrine-Related Cancer. 6:293-301 (1999).
34. Bulun SE, K Zeitoun and Kilic G: Expression of dioxin related trans-activating factors and target genes in human endometrium and endometriosis. American Journal of Obstetrics and Gynecology. 182:767-775 (2000). 
35. Bulun SE, K Zeitoun, K Takayama, E Simpson, and H Sasano: Aromatase in endometriosis: biology and clinical application. Trends in Endocrinol Metab. 11:22-27 (2000).
36. Bulun SE, K Zeitoun, K Takayama, and H Sasano: Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance. Journal of Molecular Endocrinology. 25:35-42 (2000).
37. Attia GR, K Zeitoun, D Edwards, A Johns, BR Carr, and SE Bulun: Progesterone receptor isoform A but not B is expressed in endometriosis. J.Clin Endocrinol Metab. 85:2897-2902 (2000).
38. Bulun SE, K Zeitoun, K Takayama, and H Sasano: Molecular basis for treatment of endometriosis with aromatase inhibitors. Human Reproduction Update. 6:413-418 (2000). 
39. Meng L, J Zhou, H Sasano, T Suzuki, K Zeitoun, and SE Bulun: TNFa and IL-11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively downregulating C/EBPa and PPARg: mechanism of desmoplastic reaction. Cancer Research. 61:2250-2255 (2001).
40. Zhou J, B Gurates, S Yang, S Sebastian, and SE Bulun: Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by C/EBPb. Cancer Research. 61:2328-34 (2001).
41. Sebastian S and SE Bulun: Human genome project based analysis reveals a highly complex organization of the CYP19 (aromatase P450) gene. J.Clin Endocrinol Metab. 86:4600-4602 (2001).
42. Yang S, Z Fang, B Gurates, M Tamura, J Miller, K Ferrer, and SE Bulun: Stromal progesterone receptors mediate induction of 17b-hydroxysteroid dehydrogenase type 2 expression in human endometrial epithelium: a paracrine mechanism for inactivation of estradiol. Mol Endocrinol. 15:2093-2105 (2001).
43. Yang S, Z Fang, S Takashi, S Hironobu, Z Jianfeng, B Gurates, M Tamura, K Ferrer and SE Bulun: Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins: decreased C/EBPb in endometriosis is associated with overexpression of aromatase. J.Clin Endocrinol Metab. 87:2336-2345 (2002).
44. Tamura M, S Sebastian, S Yang, Gurates B, Z Fang, and SE Bulun: Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells. J.Clin Endocrinol Metab. 87:3504-3507 (2002). 
45. Tamura M, S Sebastian, S Yang, Gurates B, Z Fang, and SE Bulun: Interleukin-1b elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinase 1 and 2. J. Clin. Endocrinol. Metab. 87:3263-3273 (2002).
46. Tamura, M, S Sebastian, S Yang, B Gurates, K Ferrer, H Sasano, and SE Bulun. Up-regulation of Cyclooxygenase-2 Expression and Prostaglandin Synthesis in Endometrial Stromal Cells by Malignant Endometrial Epithelial Cells: A paracrine mechanism mediated by PGE2 and nuclear factor-kB. J Biol Chem. 277:26208-26216 (2002).
47. Fang ZJ, S Yang, B Gurates, M Tamura, E Simpson, D Evans, SE Bulun. Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue. J. Clin. Endocrinol. Metab. 87:3460-3466 (2002).
48. Gurates B, S Sebastian, S Yang, J Zhou, M Tamura, Z Fang, T Suzuki, H Sasano, and SE Bulun: WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. J. Clin. Endocrinol. Metab. 87:4369-4377 (2002).
49. Sebastian S, K Takayama, M Shozu and SE Bulun. Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. Mol Endocrinol. 16:2243-54 (2002).
50. Zhou J, S Yang, S Sebastian, B Gurates, M Tamura, Z Fang, S Amin, K, SE Bulun: Sodium butyrate suppresses aromatase P450 expression in breast adipose fibroblasts via selectively silencing cancer-associated promoters II and I.3: a mechanism mediated by inhibition of ATF-2 phosphorylation. (J Biol Chem, in revision).
51. Shozu M, S Sebastian, K Takayama, W Hsu, M Schultz, K Neely, M Bryant, SE Bulun: Prepubertal gynecomastia due to estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. ( NEJM- in revision).

Invited Reviews:

1. Simpson ER, MS Mahendroo, JE Nichols and SE Bulun: Regulation of aromatase expression: Relationship to breast cancer. Excerpta Medica International Congress Series. 1064:269-78 (1994).
2. Simpson ER, MS Mahendroo, MW Kilgore, GD Means, SE Bulun, MM Hinshelwood, and CR Mendelson: The aromatase reaction. Adv Mol Cell Biol. 14:225-244 (1996).
3. Simpson ER, Y Zhao, VR Agarwal, MD Michael, SE Bulun, MM Hinshelwood, S Graham-Lorence, T Sun, CR Fisher, and CR Mendelson: Aromatase expression in health and disease. Rec Prog in Horm Res. 52:185-214 (1997).
4. Simpson ER, MD Michael, VR Agarwal, MM Hinshelwood, SE Bulun, and Y Zhao. Expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage. FASEB J. 11:29-36 (1997).
5. Bulun SE: The Syndrome of Aromatase Deficiency. Current Opinion in Endocrinology and Diabetes. 5:350-356 (1998).
6. Bulun SE, K Zeitoun, H Sasano, and E Simpson: Aromatase in aging women. Seminars in Reproductive Endocrinology. 17:349-358 (1999). 
7. Bulun SE: Aromatase deficiency and estrogen resistance: from molecular genetics to clinic. Seminars in Reproductive Endocrinology. 18:31-39 (2000). 
8. Simpson ER, Clyne C, Speed C, Rubin G, and SE Bulun: Tissue-specific estrogen biosynthesis and metabolism. Annals of the New York Academy of Sciences. 949:58-67 (2001). 
9. Bulun SE, S Yang, Z Fang, B Gurates, M Tamura, J Zhou, S Sebastian: Role of aromatase in endometrial disease. J Steroid Biochem Mol Biol. 79:19-25 (2001).
10. Nelson LR, SE Bulun: Estrogen production and action. J Am Acad Dermatol. 45:S116-124 (2001).
11. Takayama K, SE Bulun: Endometriosis and aromatase inhibitors. Nippon Rinsho 59:157-60.
12. Bulun SE, Yang S, Fang Z, Gurates B, Tamura M, Zhou J and Sebastian S. Estrogen production and metabolism in endometriosis. Annals of the New York Academy of Sciences. 955:75-85 (2002). 
13. Fazleabas A, Brudney A, Gurates B, Chai D, SE Bulun: A Modified Baboon Model for Endometriosis. Endometriosis. Annals of the New York Academy of Sciences. 955:308-317 (2002). 
14. Bulun SE, B Gurates, Z Fang, M Tamura, S Sebastian, J Zhou, S Amin, S Yang: Mechanisms of excessive estrogen formation in endometriosis. J. Reprod Immun. In press (2002).

CHAPTERS AND BOOK REVIEWS:

1. Bulun SE and MS Piver. Review of “Benign Diseases of the Vulva and Vagina”, 3rd ed. Kaufman RH, Friedrich EG, editors. New York, NY: Springer-Verlag, Adolescent and Pediatric Gynecology. 3:119-20 (1990).
2. Bulun SE, LS Noble, K Takayama, MD Michael, C Fisher, Y Zhao, MM Hinshelwood, Y Ito, VR Agarwal and ER Simpson. The human aromatase enzyme: from gene to clinic. In: FSH Action and Intraovarian Regulation. Fauser BJCM, editor Carnforth, UK: Parthenon Publishing Group Limited. 6:233-246 (1997).
3. Zeitoun K and SE Bulun. Review of “Hormones and Cancer”. Vedeckis WV, editor. Boston, MA: Birkhauser In: Trends in Endocrinology and Metabolism. 8:290-291 (1997).
4. Simpson ER, MD Michael, VR Agarwal, MM Hinshelwood, SE Bulun, and Y Zhao. Tissue-specific expression of the CYP19 (aromatase) gene. Leroith, D, editor. In: Advances in Molecular and Cellular Endocrinology. JAI Press Inc. 2:99-120 (1998). 
5. Bulun SE, ER Simpson and CR Mendelson. The molecular basis of hormone action. Carr BR, Blackwell RE, editors. In: Textbook of Reproductive Medicine. 2nd ed. Norwalk, CT: Appleton&Lange. 7:137-156 (1998). 
6. Bulun SE and ER Simpson. Estrogen action, breast. Knobil E, Neill JD, editors. In: Encyclopedia of Reproduction. San Diego, CA: Academic Press, Inc. 2:71-79 (1998). 
7. Bulun SE and ER Simpson. Aromatase deficiency. Martini L, Chrousos GP, editors. In: Hormone Resistance. New York: Raven Press. 467-75 (2002).
8. Nelson LR, Bulun SE: Aromatase: Glandular and Extraglandular activity. In: Reproductive Medicine: Molecular Cellular and Genetic Fundamentals. B.C.J.M. Fauser (Ed.), Parthenon Publishing, In Press.
9. Bulun SE, Adashi EY: The Physiology and Pathology of the Female Reproductive Axis Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, editors. In: Williams Textbook of Endocrinology, 10th ed, WB Saunders Company, Philadelphia, In Press.

ABSTRACTS: 

1. Bulun SE, TM Price, MS Mahendroo, ER Simpson: Failure to detect aromatase cytochrome P450 mRNA in human endometrium by means of polymerase chain reaction technology. The Society for Gynecologic Investigation, San Antonio, TX, 1992 (Oral presentation).
2. Bulun SE, O Dogan, K Crickard: Ag staining of nucleolar organizer regions assists to differentiate between benign, borderline, and malignant epithelial ovarian tumors. The Society for Gynecologic Investigation, San Antonio, TX, 1992 (Poster presentation).
3. Bulun SE, ER Simpson, MS Mahendroo: Local estrogen biosynthesis in adipose tissue from human breast quadrants correlates with the site of malignancy independent of various prognostic factors. Basic and Clinical Aspects of Aromatase: The Third International Conference on Aromatase, Bologna, Italy, 1992 (Poster presentation).
4. Bulun SE, MW Kilgore, WP Zeller, IR Rosenthal: Alternative splicing of aromatase P450 transcripts in feminizing tumor of Peutz-Jeghers syndrome. The Endocrine Society, San Antonio, TX, 1992 (Oral presentation).
5. Bulun SE, TM Price, J Aitken, ER Simpson: Distribution of aromatase cytochrome P450 transcripts in adipose tissue from human breast quadrants correlates with site of tumor. 9th International Congress of Endocrinology, Nice, France, 1992 (Poster presentation).
6. Bulun SE, TM Price, ER Simpson: Quantification of breast adipose tissue aromatase cytochrome P450 mRNA by a specific competitive polymerase chain reaction in patients with breast cancer. The American Fertility Society, New Orleans, LA, 1992 [Plenary lecture, 1992 AFS-SRE Prize Paper Award].
7. Bulun SE, ER Simpson, RA Word: Quantification of aromatase cytochrome P450 transcripts in uterine leiomyomas and proximal myometrial tissues by competitive polymerase chain reaction technology. The Society for Gynecologic Investigation, Toronto, Canada, 1993 (Oral presentation).
8. Bulun SE, ER Simpson: Levels of aromatase cytochrome P450 transcripts in adipose tissue of women at various body sites increase with advancing age. The Endocrine Society, Las Vegas, NV, 1993 (Poster presentation).
9. Bulun SE, ER Simpson: Regulation of aromatase cytochrome P450 gene expression is directed by the same promoter in fetal and adult ovaries as in estrogen-producing ovarian sex cord tumors. The American Fertility Society, Montreal, Canada, 1993 (Oral presentation).
10. Bulun SE, M Crichton, ER Simpson: Aromatase cytochrome P450 expression in adipose stromal cells is regulated by medroxyprogesterone acetate and RU486. The Society for Gynecologic Investigation, Chicago, IL, 1994 (Oral presentation).
11. Bulun SE, CH Albini, AM Brodie, MH McGillivray, W Yu, ER Simpson: Quantification of aromatase cytochrome P450 transcripts in a testicular tumor and breast tissue samples from a prepubertal boy with gynecomastia and Peutz-Jeghers syndrome using competitive RT-PCR technology. The Endocrine Society, Anaheim, CA, 1994 (Poster presentation).
12. Bulun SE, K Economos, ER Simpson: CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors. The Endocrine Society, Anaheim, CA, 1994 (Poster presentation).
13. Nichols JE, SE Bulun, ER Simpson: Aromatase activity of adipose stromal cells in culture is markedly stimulated by conditioned media from MCF-7 and T-47D breast cancer cell lines. The Endocrine Society, Anaheim, CA, 1994 (Oral presentation).
14. Bulun SE, Y Ito, M Bryant, ER Simpson: Molecular basis for increased extraglandular aromatization of plasma C19 steroids resulting in prepubertal gynecomastia. The Society for Gynecologic Investigation, Chicago, IL, 1995 (Oral presentation).
15. Nichols JE, SE Bulun, ER Simpson: Aromatase activity in adipose stromal cells in culture is markedly stimulated by interleukin-11. The Society for Gynecologic Investigation, Chicago, IL, 1995 (Poster presentation).
16. Noble LS, ER Simpson, A Johns, SE Bulun: Detection of aromatase P450 transcripts in endometriosis. The Society for Gynecologic Investigation, Chicago, IL, 1995 (SGI President’s Poster Award).
17. Bulun SE, JJ Van Wyk, G Jones, ER Simpson: Molecular basis for gynecomastia associated with aromatase expression in hepatocellular carcinoma. The Endocrine Society, Washington, DC, 1995 (Oral presentation).
18. Crichton MB, Y Zhao, JE Nichols, SE Bulun, ER Simpson: Breast cancer cell lines and tumors express cytokines which are stimulatory of aromatase expression in adipose tissue. The Endocrine Society, Washington, DC, 1995 (Poster presentation).
19. Zhao Y, JE Nichols, SE Bulun, ER Simpson: Aromatase gene expression in human adipose stromal cells: a Jak/STAT signalling pathway is involved in regulation by cytokines. The Endocrine Society, Washington, DC, 1995 (Oral presentation).
20. Bulun SE, J Rink, G Sharda, S Sharma, ER Simpson: Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast. The Endocrine Society, Washington, DC, 1995 (Poster presentation).
21. Agarwal VR, ER Simpson, SE Bulun: Use of alternative promoters of the aromatase P450 gene in human breast carcinogenesis. Cold Spring Harbor Meetings, Cancer Cells: Mechanism of Eukaryotic Transcription, New York, 1995 (Poster presentation).
22. Noble LS, ER Simpson, VR Agarwal, A Johns, SE Bulun: Regulation of aromatase expression in cultured stromal cells derived from endometriosis. The Society for Gynecologic Investigation, Philadelphia, PA, 1996 (Oral presentation).
23. Agarwal VR, SE Bulun, ER Simpson: Alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in adipose tissue of breast cancer patients. 10th International Congress of Endocrinology, San Francisco, CA, 1996 (Poster presentation).
24. Noble LS, ER Simpson, JM Putman, A Johns, SE Bulun: Aromatase P450 expression in endometriotic implants and endometriosis-derived stromal cells in culture. 10th International Congress of Endocrinology, San Francisco, CA, 1996 (Poster presentation).
25. Noble LS, K Takayama, JM Putman, DA Johns, BR Carr, SE Bulun: Molecular basis for prostaglandin E2 induction of local estrogen biosynthesis in endometriosis. The American Society for Reproductive Medicine, Boston, MA, 1996 [Plenary lecture, 1996 ASRM-SRE Prize Paper Award].
26. Zeitoun KM, K Takayama, N Moghrabi, M Putman, BR Carr, SE Bulun: Conversion of estrone to estradiol is increased in endometriosis compared with the endometrium. The Society for Gynecologic Investigation, San Diego, CA 1997 (Poster presentation).
27. Shozu M, SE Bulun, Y Zhao, ER Simpson. Expression of a novel exon I of the aromatase gene: exon I.6. The Endocrine Society, Minneapolis, MN, 1997 (Poster presentation).
28. Agarwal VR, S Sasano, K Takayama, IM Rosenthal, R Walton, ER Simpson, SE Bulun. Excessive levels of aromatase P450 and its transcripts in breast adipose tissue of a girl with pubertal macromastia. The Endocrine Society, Minneapolis, MN, 1997 (Poster presentation).
29. Zeitoun K, K Takayama, RT Gunby, BR Carr, SE Bulun. Treatment of severe endometriosis with an aromatase inhibitor: a novel indication and its molecular basis. The Society for Gynecologic Investigation, Atlanta, GA 1998 (Poster presentation).
30. Zeitoun K, N Moghrabi, IM Rosenthal, F Straus, H Sasano, K Takayama, S Andersson, SE Bulun. Aberrant expression of 17b-HSD type 3 in adrenal mass associated with isosexual precocity in a boy. The Endocrine Society, New Orleans, LA, 1998 (Oral presentation).
31. Zeitoun K, M Ebaugh, BR Carr, SE Bulun. 17b-HSD type 3 expression in a persistent ovarian tumor giving rise to recurrent gestational virilization. The Endocrine Society, New Orleans, LA, 1998 (Oral presentation). 
32. Shozu M, K Takayama, SE Bulun. Mutation in 5¢-flanking region of CYP19 gene causes excessive peripheral aromatase expression in boy with gynecomastia. The Endocrine Society, New Orleans, LA, 1998 (Oral presentation).
33. Meng L, K Zeitoun, K Takayama, H Sasano, SE Bulun. Breast cancer cells inhibit adipocyte differentiation: mechanism of desmoplastic reaction. The Endocrine Society, New Orleans, LA, 1998 (Poster presentation). 
34. Zeitoun K, A Johns, M Putman, AS Andersson, BR Carr, SE Bulun. Defective inactivation of estradiol in endometriosis in relation to deficient 17b-HSD type 2 expression. IV World Congress on Endometriosis, Quebec City, Canada, 1998 (Oral presentation). 
35. Zeitoun K, K Takayama, MD Michael, M Putman, A Johns, H Sasano, BR Carr, SE Bulun. Aromatase expression in endometriosis and its inhibition in endometrium are regulated by competitive action of two transcription factors: steroidogenic factor-1 (SF1) and chicken ovalbumin upstream promoter-transcription factor (COUP-TF). The American Society for Reproductive Medicine, San Francisco, CA, 1998 [1998 ASRM-SRE Prize Paper Award].
36. Attia G, K Zeitoun, BR Carr, and SE Bulun: Differential expression of progesterone receptor isoforms in eutopic endometrium and endometriosis. The Society for Gynecologic Investigation, 46th Annual Meeting, Atlanta, GA, 1999 (Oral presentation).
37. Zeitoun K, G Attia, D Michael, H Murakami, BR Carr, and SE Bulun: A novel inhibitory region (-517/-694 bp) in aromatase P450 confers tissue-specific inhibition of aromatase expression in eutopic endometrium. The Society for Gynecologic Investigation, 46th Annual Meeting, Atlanta, GA, 1999 (Oral presentation) [President’s Presenter Award].
38. Bulun SE, CS Mao, JA Brasel, and EK Neely. Treatment of gynecomastia and hypogonadism in disorders of excessive estrogen formation using an aromatase inhibitor. The Endocrine Society, 81st Annual Meeting, San Diego, CA. 1999. (Oral presentation)
39. Bulun S, K Zeitoun, L Noble, K Takayama, and G Attia. Aromatase: A Key Molecule in Pathophysiology of Endometriosis and A Therapeutic Target. The Endocrine Society, 81st Annual Meeting, San Diego, CA. 1999 (Invited Speaker).
40. Zhou, J and SE Bulun: TNFa and IL-11 Secreted by Malignant Breast Epithelial Cells Inhibit Adipocyte Differentiation by Selectively Inhibiting C/EBPa and PPAR?. US Army Breast Cancer Research Program (Era of Hope), Atlanta, GA. 2000 (Poster).
41. Zhou, J and SE Bulun: C/EBPß, C/EBPa and PPAR? stimulate aromatase P450 promoter II activity in human and murine adipose fibroblasts: part of an epithelial-stromal interaction in breast cancer. US Army Breast Cancer Research Program (Era of Hope), Atlanta, GA. 2000 (Poster).
42. Fang, ZJ, SJ Yang, B Gurates, , and SE Bulun: Use of transgenic knockout mice to understand the roles of estrogen and progesterone in the growth of ectopic uterine tissue as a model for endometriosis. American Society for Reproductive Medicine, 56th Annual Meeting, San Diego, CA,2000 (Oral Presentation).
43. Yang, SJ; ZJ Fang,, B Gurates, J Miller, and SE Bulun: Stromal Cell Progesterone Receptors Mediate Stimulation of Epithelial 17ß-HSD Type 2 Expression in Endometrium: Evidence for a Stromal Cell Defect Responsible for 17ß-HSD Type 2 Deficiency in Endometriosis. The Society for Gynecologic Investigation, 48th Annual Meeting, Toronto, Canada. 2001 (Poster Presentation).
44. Gurates B, S Yang, J Zhou, Z Fang, S Sebastian, and SE Bulun: Regulation of CYP1A1 gene and enzyme activity of its product by dioxin in endometrial cells. The Society for Gynecologic Investigation, 48th Annual Meeting, Toronto, Canada. 2001 (Oral presentation).
45. Tamura M, S Yang, Z Fang, S Sebastian and SE Bulun: Epithelial cell derived factors regulate the expression of Cyclooxygenase-1 and 2 in stromal cells in endometrium: a paracrine mechanism for prostaglandin formation. The Society for Gynecologic Investigation, 48th Annual Meeting, Toronto, Canada. 2001 (Oral presentation).
46. Sebastian S, M Shozu, W Hsu, J Sarkey, R Schultz, K Neely and SE Bulun: Estrogen excess caused by gain of function mutations of the CYP19 (Aromatase)gene involving the chromosome 15Q21.2-Q21.3 region. The Endocrine Society, 83rd Annual Meeting, Denver, CO. 2001. (Oral presentation).
47. Sebastian S and SE Bulun:. Physical mapping based on human genome project data reveals a highly complex genomic organization of the CYP19 (aromatase P450) gene. The Endocrine Society, 83st Annual Meeting, Denver, CO. 2001. (Poster presentation).
48. Yang S, Z Fang, B Gurates, and SE Bulun: Differential binding of C/EBP isoforms to aromatase promoter II in eutopic endometrial and endometriotic stromal cells. American Society for Reproductive Medicine, 57th Annual Meeting, Orlando, FL 2001. (Oral presentation).
49. Fang Z, S Yang, M Tamura, B Gurates and SE Bulun: Treatment with the aromatase inhibitor letrozole significantly reduced the size of ectopic uterine implants. American Society for Reproductive Medicine, 57th Annual Meeting, Orlando, FL 2001. (Oral presentation).
50. Gurates B, S Yang, Z Fang, M Tamura, S Sebastian, SE Bulun: Transcriptional regulation of the CYP1A1 gene by dioxin in eutopic endometrial and endometriotic stromal cells. American Society for Reproductive Medicine, 57th Annual Meeting, Orlando, FL 2001 (Oral presentation).
51. Tamura M, S Yang, B Gurates, Z Fang, S Sebastian, SE Bulun: Induction of cyclooxygenase-2 and prostaglandin E2 biosynthesis by epithelial cell derived factors is mediated mainly by p42/p44 mitogenactivated protein (MAP) kinase in stromal cells in endometrium. American Society for Reproductive Medicine, 57th Annual Meeting, Orlando, FL 2001 (Oral presentation).
52. Yang SJ, Fang ZJ Gurates B, Amino S, and SE Bulun: Regulation of human 17b hydroxysteroid dehydrogenase type 2 gene expression in human endometrial epithelial cells by the transcription factor Sp1. The Society for Gynecologic Investigation , 49th Annual Meeting, Los Angeles, 2002 (Oral presentation)
53. Tamura M, Sebastian S, Yang S, Gurates B, and SE Bulun: Interleukin-1b induced cyclooxygenase-2 and prostaglandin E2 synthesis in primary human endometrial stromal cells is regulated by increased mRNA stability mediated by protein kinase A, nuclear factor-kB and extracellularly regulated kinase pathways. The Society for Gynecologic Investigation, 49th Annual Meeting, Los Angeles, 2002 (Poster presentation)
54. Gurates B, Sebastian S, Yang S, Tamura M, Fang Z, Amin S, SE Bulun. A Novel response element in the human aromatase P450 promoter II confers regulation by transcription factors SF-1 and DAX-1 in Endometriosis and Ovary. The Society for Gynecologic Investigation, 49th Annual Meeting, Los Angeles, 2002 (Oral presentation).
55. Sebastian S, Takayama K, Shozu M and SE Bulun. Cloning and Functional Characterization of a Novel Promoter (I.7) of the Human CYP19 (AromataseP450) Gene that is Overexpressed in Breast Cancer and Regulated by GATA-2. The American Association of Cancer Research 92nd Annual Meeting, 2002 (Poster presentation).
56. Gurates B, S Sebastian, M Tamura, S Yang, J Zhou, Z Fang, S Amin, A Amsterdam, and SE Bulun. WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells. The Endocrine Society, 84th Annual Meeting, San Francisco, CA. 2002. (Poster presentation).
57. Gurates B, S Sebastian, S Yang, M Tamura, Z Fang, SE Bulun. Wilms' tumor 1 inhibits aromatase P450 expression in human cells and is downregulated in endometriosis vs. endometrium-derived stromal cells. American Society for Reproductive Medicine, 58th Annual Meeting, Seattle, WA, 2002. (Oral presentation).
58. Fang Z, S Yang, M Tamura, B Gurates and SE Bulun: Intact progesterone receptors are essential to counteract the proliferative effect of estrogen in a transgenic mouse model of endometriosis. American Society for Reproductive Medicine, 58th Annual Meeting, Seattle, WA, 2002. (Oral presentation).